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Thromb Haemost 2008; 99(05): 807-818
DOI: 10.1160/TH08-01-0032
DOI: 10.1160/TH08-01-0032
Theme Issue Article
Heparin and low-molecular-weight heparin
Further Information
Publication History
Received 15 January 2007
Accepted after major revision 31 March 2008
Publication Date:
30 November 2017 (online)
Summary
Heparin is one of the oldest biological medicines, and has an established place in the prevention and treatment of venous thrombosis. Low-molecular-weight heparins (LMWH) have been developed by several manufacturers and have advantages in terms of pharmacokinetics and convenience of administration. They have been shown to be at least as effective and safe as unfractionated heparin and have replaced the latter in many indications. In this article the chemistry, mechanisms of action, measurement of anticoagulant activities, and clinical status of heparin and LMWH are reviewed.
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